Process for preparing thiabendazole

Details Process for preparing thiabendazole Process for preparing thiabendazole

1993-04-30

1994-05-10

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D41704

Patent

active

053109244

ABSTRACT:
Process for preparing 2-(4-thiazolyl)-1H-benzimidazole (generic name: thiabendazole) by the acid-catalyzed condensation of o-phenyldiamine and 4-cyanothiazole in solution in water or mixtures of water with miscible co-solvents (solvents which upon mixing with water in all proportions form a homogeneous mixture, as well as, other partially miscible solvents which upon mixing with water in some proportions form a homogeneous mixture under the reaction conditions of the process of this invention).

REFERENCES:
Hofmann, Imidazole pp. 260-267 (1953).
Kutritzky, Comprehensive Heterocyclic Chemistry vol. 5 p. 470 (1984).
Sklyaroua, Zh Org. Khim 22 p. 645 (1986).
Tsuchya, Chem Pharm Bull 35 2985 (1987).

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