Process for preparing therapeutic compositions containing nanopa

Details Process for preparing therapeutic compositions containing nanopa Process for preparing therapeutic compositions containing nanopa

1995-02-14

1996-04-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424488, 424490, A61K 914

Patent

active

055101186

ABSTRACT:
A process of preparing nanoparticulate drug substances comprising the steps of: preparing a premix of the drug substance and a surface modifier, and subjecting the premix to mechanical means to reduce the particle size of the drug substance, the mechanical means producing shear, impact, cavitation and attrition.

REFERENCES:
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 5039527 (1991-08-01), Tabibi et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5228905 (1993-07-01), Grunewalder et al.
patent: 5342609 (1994-08-01), Meeh et al.
patent: 5399363 (1995-03-01), Liversidge et al.
Lachman et al, The Theory and Practice of Industrial Pharmacy, Chapter 2, "Milling", p. 45, (1986).
G. Gregoriadis, H. Da Silva, and A. T. Florence, "A Procedure for the Efficient Entrapment of Drugs in Dehydration-Rehydration Liposomes (DRVs)", Int. J. Pharm. 65, 235-242 (1990).
E. Doegito, H. Fessi, M. Appel, F. Puisieux, J. Bolard, and J. P. Devissaguet, "New Techniques for Preparing Submicronic Emulsions--Application to Amphotericine-B" STP Pharma Sciences 4, 155-162 (1994).
D. M. Lidgate, R. C. Fu, N. E. Byars, L. C. Foster, and J. S. Fleitman, "Formulation of Vaccine Adjuvant Muramyldipeptides. Part 3. Processing Optimization, Characterization and Bioactivity of an Emulsion Vehicle," Pharm Res. 6, 748-752 (1989).
H. Talsma, A. Y. Ozer, L. VanBloois, and D. J. Crommelin, "The Size Reduction of Liposomes with a High Pressure Homogenizer (Microfluidizer): Characterization of Prepared Dispersions and comparison with Conventional Methods," Drug Dev. Ind. Pharm. 15, 197-207 (1989).
D. M. Lidgate, T. Trattner, R. M. Shultz, and B. Maskiewicz, "Sterile Filtration of a Parenteral Emulsion," Pharm. Res. 9, 860-863 (1990).
R. Bomeier, and H. Chen, "Indomethacin Polymeric Nanosuspensions Prepared by Microfluidization," J. Contr. Rel. 12, 223-233 (1990).
R. Bodmeier, H. Chen, P. Tyle, and P. Jarosz, "Spontaneous Formation of Drug-Containing Acrylic Nanoparticles," J. Microencap, 8, 161-170 (1991).
F. Koosha, and R. H. Muller, "Nanoparticle Production by Microfluidization," Archiv Der Pharmazie 321, 680 (1988).
The Extra Pharmapoeia, by Martindale, 29th Edition, The Pharmaceutical Press, London, 1989.

Affiliated with

Also associated with

Rating

Process for preparing therapeutic compositions containing nanopa does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing therapeutic compositions containing nanopa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing therapeutic compositions containing nanopa will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2306617