Process for preparing the sodium salt of o-carboxybenzoyl ferroc

Details Process for preparing the sodium salt of o-carboxybenzoyl ferroc Process for preparing the sodium salt of o-carboxybenzoyl ferroc

1974-08-14

1976-05-18

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260429CY, C07F 1502

Patent

active

039578410

ABSTRACT:
This invention relates to a novel medicinal preparation for treating maladies caused by iron deficiency comprising the sodium salt of o-carboxybenzoylferrocene as the active component.
The process for preparing the sodium salt of o-carboxybenzoylferrocene consists in that reacting phthalic anhydride with ethyl alcohol at the alcohol boiling temperature, whereupon the monoethyl o-phthalate obtained is treated with thionyl chloride, after which the obtained monoethyl o-phthalate chloride is used for acylating ferrocene in the presence of a catalyst in methylene chloride medium with heating, with subsequent saponification of the obtained o-carboxylbenzoylferrocene ester and separation of the end product.

REFERENCES:
patent: 3035978 (1962-05-01), Jones et al.
patent: 3078291 (1963-02-01), Stephenson
patent: 3099669 (1963-07-01), Leigh
Derwent Publication Abstracting USSR 179309 Publ. Aug. 1966; Chem. Abstracts, V65, 2300 (1966).
Chem. Abstracts, V55, 21080c (1961).
Chem. Abstracts, V58, 9133e (1964).
Merck Manual, 1972, 12th Edition pp. 255-257, 952, 969-972.
Goodman et al. The Pharmacological Basis of Therapeutics, 3rd Edition, 1965 pp. 1403-1406.
Stedman's Medical Dictionary (1966) pp. 1158, 1181, 1205.

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