Process for preparing the cyclohexylamine salt of (+) - threo-2-

Details Process for preparing the cyclohexylamine salt of (+) - threo-2- Process for preparing the cyclohexylamine salt of (+) - threo-2-

1996-04-15

1998-01-20

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562431, C07C 5500

Patent

active

057103216

ABSTRACT:
The present invention relates to a process for preparing the cyclohexylamine salt of (+)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid and of its optical (-)-antipode, by starting from the racemate acid by means of a first crystallization from a suitable chiral base and a second crystallization from a cyclohexylamine-containing solvent. Said salt is an intermediate in the synthesis of diltiazem, a well-known calcium-antagonist drug.

REFERENCES:
patent: 4931587 (1990-06-01), Piselli
patent: 4939295 (1990-07-01), Merli et al.
patent: 5183922 (1993-02-01), Rizzi et al.

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