Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Reexamination Certificate
2005-12-19
2009-06-02
Berch, Mark L (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
Reexamination Certificate
active
07541460
ABSTRACT:
Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
REFERENCES:
patent: 4471130 (1984-09-01), Katsuki et al.
patent: 4594439 (1986-06-01), Katsuki et al.
patent: 4900847 (1990-02-01), Hanson et al.
patent: 5206244 (1993-04-01), Zahler et al.
patent: 2005/0272932 (2005-12-01), Zhou et al.
patent: 2006/0106216 (2006-05-01), Pendri et al.
patent: 2007/0060599 (2007-03-01), DiMarco et al.
patent: WO 98/09964 (1998-03-01), None
patent: WO 01/64221 (2001-09-01), None
Bonini, C. et al., “A critical outlook and comparison of enantioselective oxidation methodologies of olefins”, Tetrahedron, vol. 58, pp. 4981-5021 (2002).
Danishefsky, S.J. et al., “Novel Stereospecific Silyl Group Transfer Reactions: Practical Routes to the Prostaglandins”, J. Am. Chem. Soc., vol. 111, pp. 3456-3457 (1989).
Fleming, I., “Silyl-to-Hydroxy Conversion in Organic Synthesis”, Chemtracts—Organic Chemistry, vol. 9, pp. 1-64 (1996).
Greene, T.W. et al., Protective Groups in Organic Synthesis, Second Edition, John Wiley & Sons, Inc., publ., pp. 198-201 (1991).
Griffith, D.A. et al., “The Total Synthesis of Allosamidin. Expansions of the Methodology of Azaglycosylation Pursuant to the Total Synthesis of Allosamidin. A Surprising Enantiotopic Sense for a Lipase-Induced Deacetylation”, J. Am. Chem. Soc., vol. 118, No. 40, pp. 9526-9538 (1996).
Jones, G.R. et al., “The Oxidation of the Carbon-Silicon Bond”, Tetrahedron, vol. 52, No. 22, pp. 7599-7662 (1996).
Khanapure, S.P. et al., “An Efficient Synthesis of 4(S)-Hydroxycyclopent-2-enone”, J. Org. Chem., vol. 60, No. 23, pp. 7548-7551 (1995).
Li, G. et al., “N-Halocarbamate Salts Lead to More Efficient Catalytic Asymmetric Aminohydroxylation”, Angew. Chem. Int. Ed. Engl., vol. 35, No. 23/24, pp. 2813-2817 (1996).
Miyaji, K. et al., “Synthesis of Corey Lactone Via Highly Stereoselective Asymmetric Diels-Alder Reaction”, Tetrahedron Letters, vol. 32, No. 35, pp. 4557-4560, 1991.
Carceller et al., “Synthesis of cis-bicyco [13.3.0]oct-3-ene-2, 7-dione, a highly functionalized cyclopentanoid intermediate,” Tetrahedron Letters, vol. 25, Issue 19, 1984, pp. 2031-2034.
Pearson, A.J. et al., “Conjugate Additions of Carbon Nucleophiles to Cyclopentadienones,” Organic Letters, vol. 5, No. 14, 2003, pp. 2547-2459.
Humiliere, D. et al., “A New Enantioselective Synthesis of Highly Functionalized Cyclopentanols,” Synlett 1998, pp. 1255-1257.
Bisacchi, G.S. et al., “BMS-200475, a novel carbocyclic 2′-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro,” Bioorganic & Medicinal Chemistry Letters, vol. 7, Issue 2, 21 1997, pp. 127-132.
Ziegler, F.E., et al., “Radical cyclization studies directed toward the synthesis of BMS-200475 ‘entecavir’: the carbocyclic core,” Tetrahedron, vol. 59, Issue 45, Nov. 3, 2003, pp. 9013-9018.
Chan Yeung Yu
Rijhwani Sushil K.
Berch Mark L
Bristol--Myers Squibb Company
Chin-Chapman Jennifer T.
Epperson James
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