Process for preparing terbinafine by using platinum as catalyst

Details Process for preparing terbinafine by using platinum as catalyst Process for preparing terbinafine by using platinum as catalyst

2007-10-30

2007-10-30

Davis, Brian J. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S366000

Reexamination Certificate

active

10536312

ABSTRACT:
A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst

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Database CAPLUS on STN, Acc. No. 1981:569006, STUTZ, EP 24587 (Mar. 11, 1981) (abstract).
Alami et al., Journal of Organometallic Chemistry (2001), 624, p. 114-123.
Alami M et al: “A Two-Step Synthesis of Terbinafine” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 37, No. 1, 1996, pp. 57-58, XP004030473 ISSN: 0040-4039 the whole document.

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