Process for preparing Tc-99m tris(isonitrile) copper complexes

Details Process for preparing Tc-99m tris(isonitrile) copper complexes Process for preparing Tc-99m tris(isonitrile) copper complexes

1989-08-23

1991-07-02

Maples, John S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

424 11, C07F 1300, A61K 4902

Patent

active

050286994

ABSTRACT:
Tris(isonitrile)copper(I) complex salts with anions selected from BF.sub.4, PF.sub.6, ClO.sub.4, I, Br, Cl and CF.sub.3 COO are useful in preparing radionuclide complexes rapidly at room temperature. Preferred isonitrile ligands are ether isonitriles. The tris(isonitrile)copper(I) adducts enable technetium complexes, such as those of Tc99m, to be prepared easily just prior to their use as imaging agents.

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Synthesis and Characterization of Hexakis (Alkyl Isocyanide) and Hexakis (Aryl Isocyanide) Complexes of Technetium(I), Abrams et al., Inorg. Chem, 22(20), p. 2798 (1983).
Technetium-99m Isonitrile Complex as a Potential Myocardial Imaging Agent, Khalil et al., Nucl. Med. Comm., 6, 615-622 (1985).
A New Tc-99m-Labeled Myocardial Imaging Agent, Hexakis(+-Butylisonitrile)-Technetium(1)[Tc-99m TBl]: Initial Experience in the Human, Holman et al., The Journal of Nuclear Medicine, 25 (12), 1350-1355 (1984).
Evaluation in Dogs and Humans of Three Potential Technetium-99m Myocardial Perfusion Agents, Gerundini et al., J. Nucl. Med., 27(3), 409-416 (1986).

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