Process for preparing taxoids

Details Process for preparing taxoids Process for preparing taxoids

1995-06-07

1996-12-03

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

055809987

ABSTRACT:
The invention relates to a process for preparing taxoids of formula I herein that includes comprising the steps of esterifying a baccatin III derivative of the formula VI herein, treating the compound obtained in acidic medium, and optionally removing a protecting group to give the desired taxoid product.

REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 5254580 (1993-10-01), Chen et al.
Gu eritte-Voegelein et al., "Relationships between the Structure of Taxol Analogues and Their Antimitotic Activity," J. Med. Chem. 1991, 34, 992-998.
Klein et al., "Synthesis of Ring B-Rearranged Taxane Analogs," J. Org. Chem. 1994, 59, 2370-2373.

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