Process for preparing taxane derivatives

Details Process for preparing taxane derivatives Process for preparing taxane derivatives

1996-10-31

1997-10-14

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548216, 549510, 549511, C07D26304, C07D30514

Patent

active

056774621

ABSTRACT:
Disclosed is a compound of formula VII: ##STR1## where Ar represents an optionally substituted phenyl or .alpha.- or .beta.-naphthyl radical; R.sub.3 represents hydrogen, a C.sub.1-4 alkyl radical, a C.sub.2-4 alkenyl radical, an aralkyl radical, or an aryl radical; and R.sub.4 represents hydrogen, a C.sub.1-4 alkyl radical, a C.sub.2-4 alkenyl radical, an aralkyl radical, or an aryl radical; or alternatively R.sub.3 and R.sub.4, together with the carbon atom to which they are linked, form a 4- to 7-membered ring; and R.sub.5 represents an C.sub.1-4 alkyl radical substituted with at least one chlorine atom. The compound of formula VI may be used to manufacture a compound of formula VIII: ##STR2## where Ar, R.sub.3, R.sub.4 and R.sub.5 are defined above; G.sub.1 represents a group protecting the hydroxyl function; and where appropriate, G.sub.2 represents a group protecting the hydroxyl function.

REFERENCES:
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5319112 (1994-06-01), Kingston et al.
Gueritte-Voegelein et al., J. Med. Chem. vol. 34(3):pp. 992-998, Mar. 1991.
Kingston et al., Stud. Org. Chem. (New Trends in Nat. Prod. Chem. 1986), vol. 26:pp. 219-235, 1986.

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