Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2006-04-11
2006-04-11
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C544S215000, C544S314000, C544S316000, C544S319000, C564S084000, C564S085000, C564S086000, C564S088000
Reexamination Certificate
active
07026477
ABSTRACT:
The invention relates to a preparation process for a compound (I) or a salt thereof,in which Q, X*, Y, Z, R, R1, R2and R3are as defined in claim1,which comprisesa) ammonolyzing a comp. (II) in which Hal=halogen atom to give (III), pref.(a1) carrying out the reaction in an organic solvent mixture (org. solv. mixture) comprising (1) opt. halogenated aromatic hydrocarbons and (2) polar aprotic solvents, in a weight ratio of solv. (1): solv. (2) of 20:1 to 1:1,(b) phosgenating the comp. (III) with phenylsulfonyl isocyanate of the formula (IV), pref.(b1) in the case X*=halogen, carrying out the reaction with phosgene in an org. solv. in the presence of isocyanates R′-NCO as catalyst, where R′=(subst.) hydrocarbon, with or without addition of an amine base,(c) reacting the resulting compound (IV) in org. solv. with the aminoheterocycle H2N-Het (Het=heterocycle as in (I)) to give the comp. (I) or a salt thereof, pref.(c1) carrying out the reaction in a solv. mixture of opt. halogenated arom. hydrocarbon having a b.p. of more than 110° C. and a polar aprotic solv., where at least one of the preferred partial steps (a1) to (c1) is carried out in the process.
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Bourne Ian A.
Ford Mark James
Foster Richard W. G.
Schmidt Ernst
Vermehren Jan
Aventis CropScience GmbH
Balasubramanian Venkataraman
Frommer & Lawrence & Haug LLP
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