Process for preparing steroidal 3-oxo-4,6-dienes such as 17-hydr

Details Process for preparing steroidal 3-oxo-4,6-dienes such as 17-hydr Process for preparing steroidal 3-oxo-4,6-dienes such as 17-hydr

1977-12-02

1979-05-22

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 1900

Patent

active

041559061

ABSTRACT:
A process for preparing 17-hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid .gamma.-lactone by contacting 17-hydroxy-3-oxy-17.alpha.-pregna-3,5-diene-21-carboxylic acid .gamma.-lactone with an appropriate halogenating agent in the presence of an amine base, the corresponding hydrohalide salt thereof, and approximately 1-2 molar equivalents (relative to the lactonic starting material) of water, using a cold solvent as the contact medium, and heating the resultant mixture with a dehydrohalogenating agent, is disclosed.

REFERENCES:
patent: 3919198 (1975-11-01), Warnant et al.
Syhora et al., "Collection Czechoslov. Chem. Commun.", 31, (1966), p. 2768.
"Organic Reactions in Steroid Chemistry", by Fried et al., pp. 285 and 293.

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