Process for preparing steroid-carboxylates

Details Process for preparing steroid-carboxylates Process for preparing steroid-carboxylates

1980-05-01

1981-05-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023957, 2603971, C07J 900

Patent

active

042658160

ABSTRACT:
An alkali metal salt of a 3-(17.beta.-hydroxyandrosten-3-one 3-acetal-17.alpha.-yl)propiolic acid which is useful as an intermediate in the preparation of 3-(3-oxo-7.alpha.-acetylthio-17.beta.-hydroxyandrost-4-en-17.alpha.-yl)-pr opiolactone (spironolactone) as antialdosteronic diuretics and hypotensive agents is prepared by reacting a 17.beta.-hydroxypregnen-20-yn-3-one 3-acetal (I) with an alkali metal dimsyl (II) to give an alkali metal salt of the 17.beta.-hydroxypregnen-20-yn-3-one 3-acetal (III), and reacting the compound (III) with carbon dioxide followed by hydrolysis.

REFERENCES:
patent: 3734938 (1973-05-01), Hodosan et al.
patent: 3738983 (1973-06-01), Dryden et al.

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