Process for preparing sterilized plasma and plasma derivatives

Details Process for preparing sterilized plasma and plasma derivatives Process for preparing sterilized plasma and plasma derivatives

1982-04-14

1984-11-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

044811896

ABSTRACT:
A mammalian blood plasma or plasma derivative substantially free of active hepatitis B or non-A, non-B viruses is disclosed, the plasma being characterized by the presence of factor VIII, the percent by weight of denatured factor VIII to the sum of undenatured factor VIII and denatured factor VIII being less than 50%. The plasma is sterilized by contact with a detergent, alcohol or ether, preferably a mixture of detergent and ether, usually followed by removal of the viral sterilizing agent.

REFERENCES:
patent: 4057628 (1977-11-01), Bick
patent: 4105650 (1978-08-01), Shanbrom et al.
patent: 4222934 (1980-09-01), Hao
patent: 4305871 (1981-12-01), Shanbrom
patent: 4314997 (1982-02-01), Shanbrom
patent: 4315919 (1982-02-01), Shanbrom
patent: 4370264 (1983-01-01), Kotitschke et al.
Effect of Combined Treatment of Serum Containing Hepatitis B Virus with Beta-Propiolactone and Ultraviolet Irradiation-W. Stephan, H. Berthold, A. M. Prince Vox Sang 447 FRF b.
Effect of Combined Beta-Propiolactone/Ultraviolet Irradiation Treatment on Hepatitis B Virus-A. M. Prince, W. Stephan, Letter to the Editor, Lancet ii: 917, 1980.
Evaluation of the Effect of Betapropiolactone/Ultraviolet Irradiation (BPL/UF) Treatment of Source Plasma on Hepatitis Transmission by Factor IX Complex in Chimpanzees, Alfred M. Prince, W. Stephan and M. C. van den Ende.
A. M. Prince "Post Transfusion Hepatitis; Etiology and Prevention" Transfusion and Immunology, 81-86.
A. M. Prince "The Hepatitis B Antigen".
H. Ikram and A. M. Prince, "A Method for Coupling the Hepatitis B Surface Antigen to Aldehyde-Fixed Erythrocytes for use in Passive Hemagluttination"Journal of Virological Methods, 2, (1981), 269-275.

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