Process for preparing steffimycinol

Details Process for preparing steffimycinol Process for preparing steffimycinol

1977-03-30

1978-03-07

Tanenholtz, Alvin E.

Textiles: fiber preparation

C12D 918

Patent

active

040778444

ABSTRACT:
Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, there antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3976667 (1976-08-01), Kelly
Biochemistry, vol. 15, pp. 4139-4145, (1976).
The Journal of Antibiotics, Oct. 1975, vol. 28, No. 10, pp. 838-840.

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