Process for preparing solid unit dosage forms of ultra-low dose

Details Process for preparing solid unit dosage forms of ultra-low dose Process for preparing solid unit dosage forms of ultra-low dose

1982-09-07

1984-12-18

Silverberg, Sam

Plastic and nonmetallic article shaping or treating: processes

Forming articles by uniting randomly associated particles

Autogenously or by activation of dry coated particles

427 3, 424 16, A61K 900

Patent

active

044890265

ABSTRACT:
A process for the preparation of solid unit dosage forms is disclosed wherein a fine spray of a dilute solution of a pharmaceutically active material is gradually finely sprayed over an extended time period onto fine excipient particles undergoing agitation. Extremely small amounts of the pharmaceutically active material are deposited on the excipient particles, allowing the resulting powder to be formed into solid unit dosage forms, such as tablets, containing 100 mcg or less of the active ingredient per unit, with high content uniformity among the solid unit dosage forms.

REFERENCES:
patent: 3196827 (1965-07-01), Wurster
patent: 3836618 (1974-09-01), Stevens
patent: 3843393 (1974-10-01), Groppenbacher

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