Process for preparing solid pharmaceutical dosage forms

Details Process for preparing solid pharmaceutical dosage forms Process for preparing solid pharmaceutical dosage forms

1999-08-10

2000-12-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 424489, 424490, 424450, 424469, 424470, 424451, 424502, 424493, 424494, 424500, 424497, 424499, A61K 9127

Patent

active

061563390

ABSTRACT:
This invention relates to a process for the preparation of an oral solid rapidly disintegrating dosage form of a pharmaceutically active substance which has an unacceptable taste which process comprises: (i) forming a solution or a suspension in a solvent of a water soluble or water dispersible carrier, a filler and the pharmaceutically active substance with the unacceptable taste in association with a lipid, the weight ratio of the pharmaceutically active substance to the lipid being in the range of from 1:1 to 1:10 and the weight ratio of the carrier to the lipid being in the range of from 5:1 to 1:15; (ii) forming discrete units of the suspension or solution; and (iii) removing the solvent from the discrete units under conditions whereby unit dosages are formed comprising a network of carrier/filler carrying a dosage of the pharmaceutically active substance in association with the lipid; oral solid rapidly disintegrating dosage forms prepared by such a process are also provided.

REFERENCES:
patent: 5738875 (1998-04-01), Yarwood et al.
patent: 5853762 (1998-12-01), Myers et al.

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