Process for preparing sodium cefuroxime

Details Process for preparing sodium cefuroxime Process for preparing sodium cefuroxime

1986-12-01

1988-10-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50134

Patent

active

047757507

ABSTRACT:
There is disclosed a process for preparing sodium cefuroxime in very high purity. The process comprises reacting (6R,7R)-7-[Z-2-(fur-2-yl)-2-methoxyimino-acetamido]-3-hydroxymethylceph-3- em-4-carboxylic acid with a halosulphonyl isocyanate in an alkyl acetate solvent, hydrolyzing the resulting intermediate product, forming sodium cefuroxime by the addition of the sodium salt of a weak acid and isolating the sodium cefuroxime in high purity. The use of methyl acetate is particularly preferred and reaction can be carried out at from -25.degree. to +25.degree. C. The hydrolysis, generally in situ, may be carried out at from 10.degree. to 30.degree. C. Fewer steps are required than in previous processes and the product is of higher purity.

REFERENCES:
patent: 4079179 (1978-03-01), Christensen et al.
patent: 4298732 (1981-11-01), Strables

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