Process for preparing sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluor

Details Process for preparing sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluor Process for preparing sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluor

1994-03-17

1996-03-26

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21330

Patent

active

055021999

ABSTRACT:
Enantiomerically pure sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxy-meth yl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate is prepared by initially cyclizing a corresponding racemic ester to give the racemic lactones and then separating the latter by chromatography on a chiral stationary phase. Cleavage of the enantiomerically pure lactones with the aid of a base yields the enantiomerically pure end products.

REFERENCES:
patent: 5006530 (1991-04-01), Angerbauer et al.
patent: 5117038 (1992-05-01), Haug et al.
patent: 5169857 (1992-12-01), Angerbauer et al.
patent: 5177080 (1993-01-01), Angerbauer et al.
Hoffman et al. Journal of Medicinal Chemistry vol. 29, #2. pp. 159-169. 1986.

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