Process for preparing side chain derivatives of cyclohexapeptidy

Details Process for preparing side chain derivatives of cyclohexapeptidy Process for preparing side chain derivatives of cyclohexapeptidy

1996-02-20

1997-11-04

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

930270, C07K 764

Patent

active

056841280

ABSTRACT:
An improved process for the preparation of side chain derivatives of cyclohexapeptidyl lipopeptides represented by the formula ##STR1## wherein R.sup.1 is fully defined, is disclosed.

REFERENCES:
patent: 5159059 (1992-10-01), Balkovec et al.
patent: 5166135 (1992-11-01), Schmatz
patent: 5194377 (1993-03-01), Schwartz et al.
patent: 5202309 (1993-04-01), Schwartz et al.
patent: 5310873 (1994-05-01), Schmatz et al.
patent: 5378804 (1995-01-01), Balkovec et al.
Schwartz et al, The Journal of Antibiotics, vol. 45(12), pp. 1853-1866, (Dec., 1992).
Bouffard et al, J. Med. Chem., vol. 37, pp. 222-225, (1994).

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