Process for preparing sialic acid derivatives

Details Process for preparing sialic acid derivatives Process for preparing sialic acid derivatives

1987-08-11

1989-01-10

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 172, 536 182, 536 184, 536 187, 536 53, 536 553, 536124, C07H 506, C07H 1504

Patent

active

047974770

ABSTRACT:
The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-D-galacto-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-glycerol (3) consisting essentially of hydrolyzing a 3-O-(C.sub.1-5 alkyl(5-acetamide-4,7,8,9-tetra-O-acetyl-3,5-di-deoxy-alpha-D-glycero-D-ga lacto-2-noneuropyranosyl)onate)-1,2-di-O-tetradecyl-Sn-glycerol (1) in a single step, in an aqueous lower aliphatic alcohol solution of an alkali metal hydroxide.

REFERENCES:
patent: 3950322 (1976-04-01), Thomas et al.
patent: 4694076 (1987-09-01), Ogawa et al.
Bernthsen; Textbook of Organic Chemistry; 1932, pp. 178-185.
Noller; Chemistry of Organic Compounds 2nd Edition; 1957, pp. 165-174.

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