Process for preparing sertraline hydrochloride polymorphic...

Details Process for preparing sertraline hydrochloride polymorphic... Process for preparing sertraline hydrochloride polymorphic...

2006-06-27

2006-06-27

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S424000, C564S437000

Reexamination Certificate

active

07067700

ABSTRACT:
Sertraline hydrochloride, (1Scis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenaminehydrochloride, polymorph II is prepared by extracting or dissolving the sertraline base into ethyl acetate, adding isopropanol as a solvent, adding hydrogen chloride dissolved in ethyl acetate or in gaseous form, and finally isolating and drying sertraline hydrochloride polymorphic form II.

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