Process for preparing (s)- and (R)-.alpha.-ethyl-2-oxo-1-pyrroli

Details Process for preparing (s)- and (R)-.alpha.-ethyl-2-oxo-1-pyrroli Process for preparing (s)- and (R)-.alpha.-ethyl-2-oxo-1-pyrroli

1999-05-07

2000-09-26

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20712

Patent

active

061244732

ABSTRACT:
The present invention relates to a process for preparing (S)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of .alpha.-ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase.
This process makes it possible to achieve good production efficiency on the industrial scale.

REFERENCES:
patent: 4696942 (1987-09-01), Gobert et al.
patent: 4696943 (1987-09-01), Gobert et al.
Strube et al., Dynamic Simulation of Simulated Moving Bed Chromatographic Processes . . . , Journal of Chromatography, 769, pp. 81-91, Dec. 1997.
J. Strube et al. "Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations", Journal of Chromatography A, vol. 769, No. 1, May 2, 1997, pp. 81-92.
E. Cavoy et al., "Laboratory-developed simulated moving bed for chiral drug separations design of the system and separation of tramadol enantiomers", Journal of Chromatography A, vol. 769, No. 1, May 2, 1997, pp. 49-57.
E. Francotte et al., "Applications of simulated moving-bed chromatography to the separation of the enantiomers of chiral drugs", Journal of Chromatography A, vol. 769, May 2, 1997,No. 1, pp. 101-107.

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