Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1994-03-21
1996-12-24
Marx, Irene
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435136, 435141, 435921, 4352554, C12P 740, C12P 754, C12N 114
Patent
active
055873189
ABSTRACT:
The invention relates to a process for preparing (S)-.alpha.-methylarylacetic acids from mixtures, such as racemic mixtures, of (R)- and (S)-.alpha.-methylarylacetic acid esters by enantiospecific hydrolysis using extracellular lipases of microbial origin (EC 3.1.1.3).
REFERENCES:
patent: 4601987 (1986-07-01), Kilbanov et al.
patent: 4668628 (1987-05-01), Dahod et al.
patent: 4762793 (1988-08-01), Cesti et al.
Charles J. Sih et al, "Resolution of Enantiomers via Biocatalysis", Topics in Stereochemistry, 1989, vol. 19, pp. 63-125.
Ching-Shih et al, "Quantitative Analyses of Biochemical Kinetic Resolution of Enantiomers. 2. Enzyme-Catalyzed Esterifications in Water-Organic Solvent Biphasic Systems", Journal of the American Chemical Society, 1987, vol. 109, pp. 2812-2817.
Qu-Ming Gu et al, "A Facile Enzymatic Resolution Process for the Preparation of (+)-S-2-(6-Methoxy-2-Naphthyl) Propionic Acid (Naproxen)", Tetrahedron Letters, 1986 vol. 27, No. 16, pp. 1763-1766.
Bernard Cambou et al, "Lipase-Catalyzed Production of Optically Active Acids via Asymmetric Hydrolysis of Esters", Applied Biochemistry and Biotechnology, 1984, vol. 9, pp. 255-260.
Bernard Cambou et al, "Comparison of Different Strategies for the Lipase-Catalyzed Preparative Resolution of Racemic Acids and Alcohols: Asymmetric Hydrolysis, Esterification, and Transesterification", Biotech. and Bioeng., 1984, vol. 26, pp. 1449-1454.
William D. Wilson, "Enantioselective Hydrolysis of 3-Hydroxy-3-methylalkanoic Acid Esters with Pig Liver Esterase", Journal of Org. Chem., 1983, vol. 48, No. 22, pp. 3960-3966.
Ching-Shih, "Quantitative Analysis of Biochemical Kinetic Resolutions of Enantiomers", Journal of the American Chemical Society, 1982, vol. 104, No. 25, pp. 7294-7299.
Shinobu Iriuchijma et al, "Asymmetric Hydrolysis of (+/-)-.alpha.-Substituted Carboxylic Acid Esters with Microorganisms", Agric. Biol. Chem., 1981, pp. 1389-1392.
M. Bodansky et al, "Peptide Synthesis", Interscience, 1966, Chapter V, pp. 98-109.
Marx Irene
Wisconsin Alumni Research Foundation
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