Process for preparing rimantadine

Details Process for preparing rimantadine Process for preparing rimantadine

1984-05-23

1985-11-05

Warren, Charles F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564453, 564456, C07C 8511

Patent

active

045515522

ABSTRACT:
A low temperature and pressure process for preparing rimantadine in high yields from 1-adamantyl methyl ketoxime is provided. The process comprises contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a low temperature and pressure, e.g., room temperature and a pressure of about 25-115 psia (170-790 KPa) are preferred.

REFERENCES:
patent: 3352912 (1967-11-01), Prichard
patent: 4100170 (1978-06-01), Shetty
patent: 4248891 (1981-02-01), Inamoto et al.
Synthetic Methods of Organic Chemistry, W. Theilheimer vol. 9, p. 17, _(1955).
Synthetic Methods of Org. Chem., W. Theilheimer, vol. 18, p.15, (1964).
P. E. Aldrich et al., Antiviral Agents. Structure-Activity Relationships of _Compounds Related to 1-Adamontanamine, J. Med. Chem., 14(6), 535-43, _(1971).

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