Process for preparing reagent for measuring endotoxin

Details Process for preparing reagent for measuring endotoxin Process for preparing reagent for measuring endotoxin

1989-03-15

1991-09-10

Rosen, Sam

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

435 4, 435 23, 436501, G01N 33579

Patent

active

050473530

ABSTRACT:
A reagent obtained by bringing an extracted solution of horseshoe crab hemocyte lysate into temporary contact with a treating agent such as a water-insoluble polysaccharide containing .beta.-1,3-glucosidic linkage and freeing the extracted solution from said treating agent is effective for specifically measuring endotoxin.

REFERENCES:
patent: 4038029 (1977-07-01), Teller et al.
patent: 4606824 (1986-08-01), Chu et al.
Obayashi et al., A New Chromogenic Endotoxin-Specific Assay Using Recombined Limulus Coagulation Enzymes . . . , Clinica Chimica Acta, 149 (1985) 55-65.
Kakinuma et al., Biochemical and Biophysical Research Communications, 101, 434-439, (1981).
Homma et al., Bacterial Endotoxin, 365-382, (1984).
Patent Abstracts of Japan, vol. 8, No. 114, May 26, 1984.
Chemical Abstracts, vol. 95, No. 15, Oct. 12, 1989, p. 27.
International Publication No. WO 83/02123, published Jun. 23, 1983.

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