Process for preparing rapidly disintegrating granulates

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424489, 424490, 424494, 424495, 424497, 424498, A61K 950

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active

048407992

ABSTRACT:
The present invention relates to a process for preparing a rapidly disintegrating core granulate containing a pharmaceutically active compound, which granulate is optionally intended to be coated with a release determining coating, as well as such cores, whereby one adds a pharmaceutically active compound, optionally together with an emulsifier, to a solvent, and optionally treats the composition obtained intensively, optionally while reducing its particle size, distributes the treated composition obtained over a bed of a solid, preferably water soluble material, and dries the agglomerates thus obtained to the so as to form a rapidly disintegrating core granulate.

REFERENCES:
patent: 4456628 (1984-06-01), Bauer et al.
patent: 4525339 (1985-06-01), Behl et al.
patent: 4533562 (1985-08-01), Ikegami et al.
patent: 4673564 (1987-06-01), Kawata et al.

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