Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2005-04-12
2008-11-04
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
C435S119000
Reexamination Certificate
active
07445916
ABSTRACT:
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 4316885 (1982-02-01), Rakhit
patent: 4650803 (1987-03-01), Stella et al.
patent: 5023264 (1991-06-01), Caufield et al.
patent: 5078999 (1992-01-01), Warner et al.
patent: 5080899 (1992-01-01), Sturm et al.
patent: 5100883 (1992-03-01), Schiehser et al.
patent: 5118667 (1992-06-01), Adams et al.
patent: 5118678 (1992-06-01), Kao et al.
patent: 5120842 (1992-06-01), Failli et al.
patent: 5130307 (1992-07-01), Failli et al.
patent: 5162333 (1992-11-01), Failli et al.
patent: 5177203 (1993-01-01), Failli et al.
patent: 5221670 (1993-06-01), Caufield
patent: 5233036 (1993-08-01), Hughes
patent: 5252579 (1993-10-01), Skotnicki
patent: 5256790 (1993-10-01), Nelson
patent: 5258389 (1993-11-01), Gooulet et al.
patent: 5260300 (1993-11-01), Hu
patent: 5262423 (1993-11-01), Kao
patent: 5302584 (1994-04-01), Kao et al.
patent: 5362718 (1994-11-01), Skotnicki et al.
patent: 5373014 (1994-12-01), Failli et al.
patent: 5378696 (1995-01-01), Caufield
patent: 5378836 (1995-01-01), Kao et al.
patent: 5385908 (1995-01-01), Nelson
patent: 5385909 (1995-01-01), Nelson
patent: 5385910 (1995-01-01), Ocain et al.
patent: 5389639 (1995-02-01), Failli et al.
patent: 5391730 (1995-02-01), Skotnicki et al.
patent: 5411967 (1995-05-01), Kao et al.
patent: 5434260 (1995-07-01), Skotnicki et al.
patent: 5463048 (1995-10-01), Skotnicki et al.
patent: 5480988 (1996-01-01), Kao et al.
patent: 5480989 (1996-01-01), Kao et al.
patent: 5489680 (1996-02-01), Failli et al.
patent: 5491231 (1996-02-01), Nelson
patent: 5504091 (1996-04-01), Molnar-Komber et al.
patent: 5563145 (1996-10-01), Failli et al.
patent: 5665772 (1997-09-01), Cottens et al.
patent: 5780462 (1998-07-01), Lee et al.
patent: 6261813 (2001-07-01), Khmelnitsky
patent: 6277983 (2001-08-01), Shaw et al.
patent: 7268144 (2007-09-01), Gu et al.
patent: 2001/0010920 (2001-08-01), Molnar-Kimber
patent: 2004/0010920 (2004-01-01), DeLillo
patent: 2005/0033046 (2005-02-01), Chew et al.
patent: 0464 895 (1992-01-01), None
patent: 525960 (1993-03-01), None
patent: 2 281 294 (1995-03-01), None
patent: WO 92/05179 (1992-02-01), None
patent: WO 94/24304 (1994-10-01), None
patent: WO 94/25022 (1994-11-01), None
patent: WO 94/25072 (1994-11-01), None
patent: WO 95/28406 (1995-10-01), None
patent: WO 98/45333 (1998-10-01), None
M. Adamczyk et al, Tetrahedron Letters, 35(7):1019-1022 1994.
Khmelnitsky et al, Synthesis of Water-Soluble Paclitaxel Derivatives by Enzymatic Acylation, J. Am. Chem. Soc. 119, pp. 11554-11555, (1997).
Shibatani et al, Enzymatic Synthesis of Vinyl Sugar Ester in Dimethylformamide, Biotechnology, Letters, vol. 19, No. 6, pp. 511-514, (Jun. 1997).
Park et al, Enzyme-Catalyzed Synthesis of Sugar-Containing Monomers and Linear Polymers, Biotechnology and Bioengineering, vol. 70, No. 2, (Oct. 20, 2000).
R. Morris, J. Heart Lung Transplant 11(pt. 2):197 (Jan.-Feb. 1992).
Cai Ping
Gu Jianxin
Ruppen Mark E.
Howson & Howson LLP
Lilling Herbert J.
Rubin David
Wyeth
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