Process for preparing R-(-)carnitine from...

Details Process for preparing R-(-)carnitine from... Process for preparing R-(-)carnitine from...

2007-07-24

2007-07-24

Parsa, J. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S596000

Reexamination Certificate

active

11175356

ABSTRACT:
An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formu (I):where X1and X2, which may be the same or different, are hydroxy, C1-C4alkoxy, phenoxy, halogen, or X1and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.

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patent: WO 99 05092 (1999-02-01), None
Arnold et al, Synthesis of Stereoregular Poly(alkyl malolactonates), Makromolekulare Chemi, Macromolecular Symposia, No. 6, 1986, pp. 285-303.
Frick et al, “An Efficient Synthesis of Enantiomerically Pure (R)-(2-Benzyloxyethyl) oxirane from (S)-Aspartic Acid”, SYNTHESIS, No. 7, Jul. 1992, pp. 621-623.
Merck Index, Tenth Edition, 1983, Merck & Co., Inc., New Jersey, pp. 1377 and 2073.

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