Process for preparing (R)-2-bromo-3-phenyl-propionic acid

Details Process for preparing (R)-2-bromo-3-phenyl-propionic acid Process for preparing (R)-2-bromo-3-phenyl-propionic acid

1999-02-17

2000-08-15

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562426, 562556, 562557, C07C15309, C07C149437

Patent

active

061039314

ABSTRACT:
It is described a process for preparing (R)-2-bromo-3-phenyl-propionic acid starting from (D)-phenyl-alanine, sodium nitrite and concentrated hydrobromic acid in a mixture of an aqueous solvent and a solvent selected from the group consisting of halogenated hydrocarbons and aromatic hydrocarbons.

REFERENCES:
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 5238932 (1993-08-01), Flynn et al.
patent: 5366973 (1994-11-01), Flynn et al.
patent: 5504080 (1996-04-01), Karanewsky
patent: 5508272 (1996-04-01), Robl
"Preparation of a-Bromo-and-a-Chlorocarboxylic Acids from a-Amino Acids.sup.1)"; George Olah et al.; Helvetica Chimica Acta, vol. 66, Fasc. 4, (1983) pp. 1028-1030.
"Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means to Design Potent Dual Inhibitors" Pascale Coric et al.; J. Med. Chem. 1996, vol. 39, pp. 1210-1219.
"Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action", Marie-Claude Fournie-Zaluski et al.; J. Med. Chem. 1996, vol. 39, pp. 2594-2608.
Synthesis of C.sub.2 -Symmetric HIV Protoase Inhibitors With Sulfur-Containing Control Units; Andrew Spaltenstein et al.; Tetrahedron Letters, vol. 34, No. 9, pp. 1457-1460. 1993.
H. Inoue et al., "A New Enantioselective Synthesis of (2R, 3S) -3-(4-methoxyphenyl) Glycidic Ester via the Enzymatic Hydrolysis of Erythro-N-Acetyl-Beta-(4-MethoxyphenylSerine", Chemical & Pharmaceutical Bulletin, vol. 41, No. 9, Sep. 1993, pp. 1521-1523.

Affiliated with

Also associated with

Rating

Process for preparing (R)-2-bromo-3-phenyl-propionic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing (R)-2-bromo-3-phenyl-propionic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing (R)-2-bromo-3-phenyl-propionic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2008737