Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine...

Details Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine... Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine...

2005-10-04

2005-10-04

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S496000

Reexamination Certificate

active

06951853

ABSTRACT:
Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as DNA sequence selective agents which are useful as potential antitumour agents. In particular, the present invention relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. These compounds have the formula XIV shown below:

REFERENCES:
patent: 6362331 (2002-03-01), Kamal et al.
patent: 00/12508 (2000-03-01), None
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Thurston, David E. and D. Subhas Bose. “Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines”,Chem. Rev.(1994), 94, pp 433-465.
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