Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-09-12
1996-07-09
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546318, 546327, C07D21381, C07D21356
Patent
active
055346359
ABSTRACT:
It has been found that pyridine-2-carboxamides of the formula ##STR1## wherein R is amino or a residue convertible into amino, and pharmaceutically usable acid addition salts of that carboxamide in which R is amino can be prepared in a simple manner and in good yield by reacting 2,5-dichloropyridine in the presence of a palladium-phosphine catalyst with an alkyne of the formula
REFERENCES:
patent: 2749350 (1956-06-01), Nowlin
patent: 3862159 (1975-01-01), Umezawa et al.
patent: 4764522 (1988-08-01), Imhof et al.
Tilley, et al., J. Org. Chem. 53,386 (1988).
Sakamoto, et al., Chem. Pharm. Bull. 36,1890 (1988).
Sonogashira, et al., Tetrahedron Letters, 50, 4467 (1975).
Lee, et al., J. Org. Chem. 44, 2726 (1979).
Chem. Abstrs. vol. 95(9) Abstr. No. 80892-S Aug. 31, 1981.
Chem. Abstrs. vol. 99(7) Abstr. No. 53 823-W Aug. 15, 1983.
Chem. Abstr. vol. 73(25) Abstr. No. 130 851-W, Dec. 21, 1970.
Chem. Abstr. vol. 105(11) Abstr. No. 97 323e, Sep. 15, 1986.
Chem. Abstr. vol. 109(25) Abstr. No. 231 063h, Dec. 19, 1988.
R. F. Heck, Palladium Reagents In Organic Synthesis, Academic Press (1985) pp. 299-306, 348-362.
Sakamoto, et al., Palladium (o)-Catalyzed Condensation of Bromopyridines With .alpha.-Substituted Acetonitriles, Heterocycles, 27(6) 1353 (1988).
Scalone Michelangelo
Vogt Peter
Ciambrone Coletti Ellen
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Rotman Alan L.
LandOfFree
Process for preparing pyridine-2-carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing pyridine-2-carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing pyridine-2-carboxamides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1868345