Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1979-07-11
1981-02-24
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546153, 546155, 560 20, 560 38, 560 39, C07D48704
Patent
active
042529450
ABSTRACT:
A process is provided for preparing pyrazolo-[1,5-c]quinazoline derivatives of the structure ##STR1## wherein X is O or S; R.sup.1 is hydrogen, lower alkyl, hydroxymethyl, phenyl-lower alkyl, phenyl or phenyl substituted with halogen, lower alkyl, lower alkoxy, or trifluoromethyl; R.sup.2 is lower alkoxy, phenyl-lower alkoxy, phenoxy, or phenoxy substituted with lower alkyl or lower alkoxy; and R.sup.3 and R.sup.4 are the same or different and are selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, lower alkanoyloxy of 1 to 4 carbons, nitro, benzyloxy, benzyloxy having a single monolower alkoxy substituent, halogen, hydroxy, and trifluoromethyl, wherein quinolone compounds of the structure ##STR2## which are new intermediates, are reacted with a hydrazine compound to form a 5-(2-aminophenyl)-pyrazole which is then cyclized to the product.
In addition, the above product may be reacted with a halogen acid to form the corresponding hydroxymethyl compound.
REFERENCES:
patent: 3313815 (1967-04-01), Wolfe et al.
patent: 3899508 (1975-08-01), Wikel
patent: 4035368 (1977-07-01), Erickson
patent: 4076818 (1978-02-01), Vogt
patent: 4107167 (1978-08-01), Lorenz et al.
patent: 4112096 (1978-09-01), Vogt
patent: 4119720 (1978-10-01), Hardtmann
patent: 4145420 (1979-03-01), Vogt
Kirk-othmer, Encyclopedia of Chemical Technology, vol. 8, pp. 472-473, John Wiley & Sons, Inc. (1965).
Fieser, et al., Reagents for Organic Synthesis, John Wiley & Sons, New York, 1967, pp. 451, 1024.
Fieser, et al., Reagents for Organic Synthesis, vol. 4, John Wiley & Sons, New York, 1974, p. 250.
Noller, Chemistry of Organic Compounds, 3rd ed., W. B. Saunders Co., Philadelphia, 1965, pp. 183-186.
Conley Richard A.
High Leroy B.
Lam Margaret M.
Daus Donald G.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Rivers Diana G.
Rodney Burton
LandOfFree
Process for preparing pyrazolo[1,5-c]-quinazoline derivatives an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for preparing pyrazolo[1,5-c]-quinazoline derivatives an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing pyrazolo[1,5-c]-quinazoline derivatives an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1410491