Process for preparing purified S-BEL and R-BEL and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S460000, C514S473000, C549S273000

Reexamination Certificate

active

07741344

ABSTRACT:
A process for resolution of racemic BEL into its individual enantiomeric constituents by chiral HPLC. A method for determining the role of specific isoforms of iPLA2in biologic processes.

REFERENCES:
patent: 5208244 (1993-05-01), Weiss
patent: 9824396 (1998-06-01), None
patent: WO 98/24396 (1998-11-01), None
Naruto et a J. Am. Chem. Soc. 107, pp. 5262-5270 (1985).
Kinsy et al Am. J. Physiol. Renal Physiol 292, pp. 853-860 (2007).
Ackermann et al, J. Biol. Chem. vol. 270 No. 1 pp. 445-450 (1995).
Feitsma et al, Pharm. Week. Sci. Ed. vol. 10 (1988) pp. 1-11.
Gilabert et al, Analy. Chim. Acta (2002) pp. 319-335.
Porter, Pure. & Appl. Chem. vol. 63, No. 8, pp. 1119-1122 (1991).
Ackermann et al., “Inhibition of Macrophage Ca2+-Independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones,” J. Biol. Chem., 270(1):445-450 (1995).
Feitsma et al., “Chromatographic Separation of Enantiomers,” Pharmacy World & Science, 10(1):928-1231 (1988).
Gilbert et al., “Chromatographic Analysis of Lipoxygenase Products,” Analytica Chimica Acta, 465:319-335 (2002).
Jenkins et al., “Identification of Calcium-Independent Phospholipase A2 (iPLA2) Beta, and Not iPLA2γ, as the Mediator of Arginine Vasopressin-induced Arachidonic Acid Release in A-10 Smooth Muscle Cells,” J. Biol. Chem., 277(36):32807-32814 (2002).
Kinsey et al., “Identification of Calcium-independent phospholipase A2γ in Mitochondria and its Role in Mitochondrial Oxidative Stress,” Am. J. Physiol. Renal. Physiol., 292:F853-F860 (2007).
Porter, “Resolution of Chiral Drugs,” Pure & Appl. Chem., 63(8):1119-1112 (1991).
Gross, “Activation of Calcium-independent Phospholipase A2 by Depletion of Internal Calcium Stores,” Biochem. Soc. Trans., 26:345-349 (1998).
Ma et al., “The Molecular Biology of the Group VIA Ca2+-Independent Phospholipase A2,” Prog. Nucleic Acid Res. Mol. Biol., 67:1-33 (2001).
Miyake et al., “Multiple Phospholipase A2 Activities in Canine Vascular Smooth Muscle,” Biochimica et Biophysica Acta, 1165:167-176 (1992).
Gross et al., “Rat and Human Pancreatic Islet Cells Contain a Calcium Ion Independent Phospholipase A2 Activity Selective for Hydrolysis of Arachidonate Which is Stimulated by Adenosine Triphosphate and is Specifically Localized to Islet Beta-Cells,” Biochemistry, 32(1):327-336 (1993).
Ramanadham et al., “Characterization of an ATP-Stimulatable Ca2+-Independent Phospholipase A2 from Clonal Insulin-Secreting HIT Cells and Rat Pancreatic Islets: A Possible Molecular Component of the Beta-Cell Fuel Sensor,” Biochemistry, 33(23):7442-7452 (1994).
McHowat et al., “Calcium-Independent Phospholipase A2 in Isolated Rabbit Ventricular Myocytes,” Lipids, 33(12):1203-1212 (1998).
Wolf et al., “Long-Term Potentiation Requires Activation of Calcium-Independent Phospholipase A2,” FEBS Letters, 377:358-362 (1995).
Gross et al., “Nitric Oxide Activates the Glucose-dependent Mobilization of Arachidonic Acid in a Macrophage-like Cell Line (RAW 264.7) That is Largely Mediated by Calcium-independent Phospholipase A2,” J. Biol. Chem., 270(25):14855-14858 (1995).
Murakami et al., “Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways,” J. Biol. Chem., 274(5):3103-3115 (1999).
Akiba et al., “Involvement of Group VI Ca2+-independent Phospholipase A2 in Protein Kinase C-dependent Arachidonic Acid Liberation in Zymosan-stimulated Macrophage-like P388D1 Cells,” J. Biol Chem., 274(28):19906-19912 (1999).
Tran et al., “The Assembly of Very Low Density Lipoproteins in Rat Hepatoma McA-RH7777 Cells is Inhibited by Phospholipase A2 Antagonists,” J. Biol. Chem., 275(32):25023-25030 (2000).
Alzola et al., “Activation by P2X7 Agonists of Two Phospholipases A2 (PLA2) in Ductal Cells of Rat Submandibular Gland,” J. Biol. Chem., 273(46):30208-30217 (1998).
McHowat et al., “Endothelial Cell PAF Synthesis Following Thrombin Stimulation Utilizes Ca2+-Independent Phospholipase A2,” Biochemistry, 40(49):14921-14931 (2001).
Ma et al., “Pancreatic Islets Express a Ca2+-Independent Phospholipase A2 Enzyme That Contains a Repeated Structural Motif Homologous to the Integral Membrane Protein Binding Domain of Ankyrin,” J Biol. Chem., 272(17): 11118-11127 (1997).
Hazen et al., “Suicide Inhibition of Canine Myocardial Cytosolic Calcium-independent Phospholipase A2,” J. Biol. Chem., 266(11):7227-7232 (1991).
Balsinde et al., “Bromenol Lactone Inhibits Magnesium-dependent Phosphatidate Phosphohydrolase and Blocks Triacylglycerol Biosynthesis in Mouse P388D1 Macrophages,” J Biol. Chem., 271(50):31937-31941 (1996).
Balboa et al., “Involvement of Phosphatidate Phosphohydrolase in Arachidonic Acid Mobilization in Human Amnionic WISH Cells,” J Biol. Chem., 273(13):7684-7690 (1998).
Baek et al., “Halo Enol Lactone Inhibitors of Chymotrypsin: Burst Kinetics and Enantioselectivity of Inactivation,” Biochem. Biophys. Res. Comm., 178(3):1335-1342 (1991).
Dixon et al., “Acylation of the Enzymatic Site of δ-Chymotrypsin by Esters, Acid Anhydrides, and Acid Chlorides,” J. Biol. Chem., 225:1049-1059 (1957).
Bligh et al., “A Rapid Method of Total Lipid Extraction and Purification,” Canadian J. Biochem. Physiol., 37(8):911-917 (1959).
Ikegaki et al., “Glutaraldehyde Fixation of the Primary Antibody-Antigen Complex on Nitrocellulose Paper Increases the Overall Sensitivity of Immunoblot Assay,” J. Immunol. Meth., 124:205-210 (1989).
Isenovic et al., “Role of Ca2+-Independent Phospholipase A2 in the Regulation of Inducible Nitric Oxide Synthase in Cardiac Myocytes,” Hypertension, 35(2):249-254 (2000).
Daniels et al., “Haloenol Lactones,” J . Biol. Chem., 258(24):15046-15053 (1983).
Chakravarty et al., “Haloenol Lactones: Enxyme-Activated Irreversible Inactivators for Serine Proteases,” J. Biol. Chem., 257(2):610-612 (1982).
Daniels et al., “Halo Enol Lactones: Studies on the Mechanism of Inactivation of Alpha-Chymotrypsin,” Biochem., 25(6):1436-1444 (1986).
Baek et al., “Alternate Substrate Inhibitors of an Alpha-Chymotrypsin: Enantioselective Interaction of Aryl-Substituted Enol Lactones,” Biochem., 29(18):4305-4311 (1990).
Lin et al., “Cytosolic Phospholipase A2 is Coupled to Hormonally Regulated Release of Arachidonic Acid,” Proc. Natl. Acad. Sci. USA, 89:6147-6151 (1992).
Qui et al., “Protein Kinase C-dependent and -independent Pathways of Mitogen-activated Protein Kinase Activation in Macrophages by Stimuli that Activate Phospholipase A2,” J. Biol. Chem., 269(30):19480-19487 (1994).
Qui et al., “The Role of Calcium and Phosphorylation of Cytosolic Phospholipase A2 in Regulating Arachidonic Acid Release in Macrophages,” J. Biol. Chem., 273(14):8203-8211 (1998).
Olivero et al., “Role of Protein Phosphorylation in Activation of Phospholipase A2 by the Polychlorinated Biphenyl Mixture Aroclor 1242,” Toxicol. Appl. Pharm., 163:9-16 (2000).
Waggoner et al., “Structural Organization of Mammalian Lipid Phosphate Phosphatases: Implications for Signal Transduction,” Biochim. Biophys. Acta, 1439:299-316 (1999).
Nanjundan et al., “Pulmonary Lipid Phosphate Phosphohydrolase in Plasma Membrane Signalling Platforms,” Biochem. J., 358:637-646 (2001).
Hooks et al., “Lysophosphatidic Acid-Induced Mitogenesis is Regulated by Lipid Phosphate Phosphatases and is Edg-receptor Independent,” J. Biol. Chem., 276(7):4611-4621 (2001).
Ramanadham et al., “Studies of the Role of Group VI Phospholipase A2 in Fatty Acid Incorporation, Phospholipid Remodeling, Lysophosphatidylcholine Generation, and Secretagogue-induced Arachidonic Acid Relea

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for preparing purified S-BEL and R-BEL and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing purified S-BEL and R-BEL and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing purified S-BEL and R-BEL and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4176808

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.