Process for preparing prostaglandin E1, E2 and analogs thereof u

Details Process for preparing prostaglandin E1, E2 and analogs thereof u Process for preparing prostaglandin E1, E2 and analogs thereof u

1995-03-10

1997-04-08

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

549416, 549422, 549427, 549505, 560121, 560122, 562503, 562504, C07F 718

Patent

active

056189591

ABSTRACT:
A process for synthesizing prostaglandin E.sub.1, E.sub.2 and derivatives thereof is provided. The process is a "one-pot" method in which 2-furyllithium, copper cyanide, a lower alkyllithium reagent and either an (E)-alkenylstannane or a halogenide are combined with cyclopentenone (II) ##STR1## in which A, R.sup.6 and R.sup.7 are as defined herein. The reaction gives rise to the desired prostaglandin product in yields of 80% or higher.

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