Process for preparing prostaglandin analogs

Details Process for preparing prostaglandin analogs Process for preparing prostaglandin analogs

1992-07-08

1993-10-12

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556112, C07F 718, C07C 6120

Patent

active

052527638

ABSTRACT:
A process for preparing higher order cuprate complexes by reacting an alkyne with zirconocene chloride hydride to produce a zirconium intermediate which is reacted with an alkyllithium and a first copper reagent selected from R.sup.2 Cu(CN)Li or the mixture CuCN and R.sup.2 Li to produce a higher order cuprate complex.

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Schwartz, Jeffrey, Transition Metal Hydride Reagents for Organic etc., J. Organomet. Chem. Library, 1, 461-488, Jan. 1976.
B. H. Lipshutz Applications of Higher-Order Mixed etc. Synthesis Reviews No. 4, 334,339 Apr. 1987.
K. F. Bernardy et al Prostaglandins and Congeners. 20. Synthesis of etc. The Journal of Organic Chemistry vol. 44, No. 9 1438-1447 Apr. 1979.
B. H. Lipshutz et al Hydrozirconation-Transmetalation. A Mild, etc. J. Am. Chem. Soc. vol. 112 7440-7441 Jan. 1990.
K. A. Babiak et al. One-Pot Synthesis of Protected Prostaglandins etc. J. Am. Chem. Soc. vol. 112 7741-7442 Jan. 1990.
M. J. Loots et al. Formaldehyde Trapping of Zirconium Enolates: etc. Tetrahedron Letters No. 45 4382 Jan. 1978.

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