Process for preparing pregn-20-yne compounds and novel product p

Details Process for preparing pregn-20-yne compounds and novel product p Process for preparing pregn-20-yne compounds and novel product p

1976-05-28

1977-10-25

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 7100

Patent

active

040555623

ABSTRACT:
A process for preparing 17.beta.-hydroxysteroido[2,3-d]isoxazoles substituted at the 17.alpha.-position by an ethynyl or substituted ethynyl group comprising reacting a 17-oxosteroido[2,3-d]isoxazole with the appropriate ethynylmagnesium halide, substituted ethynylmagnesium halide, monolithium acetylide or substituted monolithium acetylide. The process affords a novel compound, 21-trifluoromethyl-17.alpha.-pregn-4-en-20-yno[2,3-d]isoxazol-17-ol, which has estrogenic activity.

REFERENCES:
patent: 3790564 (1974-02-01), Pierdet et al.
JACS, vol. 83 (1961) p. 4663-4664, by Fried et al.

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