Process for preparing polyprenyl carboxylic acid derivatives

Details Process for preparing polyprenyl carboxylic acid derivatives Process for preparing polyprenyl carboxylic acid derivatives

1982-06-28

1984-10-02

Wiseman, Thomas

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435132, 435189, 435253, 435872, C12P 740, C12P 700, C12N 902, C12N 120

Patent

active

044748817

ABSTRACT:
A process is disclosed for the preparation of a compound having the general formula: ##STR1## wherein n is an integer of from 2 to 4, R.sub.1 is an ester-forming moiety effective as a protecting group for a carboxyl group, and R.sub.2 is hydroxymethyl, formyl or carboxyl. The compounds (I) are useful as intermediates for the preparation of polyprenyl compounds having hypotensive and anti-ulcer activity. The process of the invention includes cultivating a microorganism selected from a strain of the genus Nocardia called BPM 1613, FERM-P No. 1609, Corynebacterium equi IAM 1038, Candida lipolytica IFO 0746, and Mycobacterium smegmatis IFO 3083, in a nutritive culture medium, in the presence of a compound having the general formula: ##STR2## wherein R.sub.3 is an ester-forming moiety effective as a protecting group for a carboxyl group, whereby the microorganism utilizes the compound (II) as a carbon source and oxidizes the compound (II), thereby converting the compound (II) into the compound (I).

REFERENCES:
patent: 4338251 (1982-07-01), Sato et al.
patent: 4386227 (1983-05-01), Sato et al.

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