Process for preparing polynucleotides on a solid support in a ti

Details Process for preparing polynucleotides on a solid support in a ti Process for preparing polynucleotides on a solid support in a ti

1994-12-14

1999-02-09

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2534, C07H 100, C07H 102

Patent

active

058696431

ABSTRACT:
The present invention relates to a process for preparing polynucleotides on a solid support in a reactor in the form of a column through which solutions of reagents and/or solvents are circulated, wherein the solid phase constituting said solid support is immobilized in said reactor, and said solutions migrate in the column and through the solid phase according to a frontal progression, such that the successive solutions from each step of a synthesis cycle do not mix at all, or very little.
The subject of the present invention is also a reactor consisting of a column completely filled with particles of porous materials constituting the solid support, and a synthesis device including such a reactor.

REFERENCES:
patent: 4517338 (1985-05-01), Urdea et al.

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