Process for preparing piroxicam/cyclodextrin complexes, the prod

Details Process for preparing piroxicam/cyclodextrin complexes, the prod Process for preparing piroxicam/cyclodextrin complexes, the prod

1991-03-27

1992-11-17

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, 5142265, 5147723, 514778, 514770, 514499, 514501, 514964, 514965, 424464, 424465, 424468, 424469, 424470, 424489, A61K 918, A61K 920, A61K 4702, A61K 4730

Patent

active

051643804

ABSTRACT:
A process for preparing complexes of piroxicam with cyclodextrins in which the two components in the powder state are premixed and then co-ground in a high energy mill in the presence of steam.
The products obtained have technological, physical and biopharmacological characteristics which are advantageous compared with those of liquid-state complexes obtained by traditional methods, and are suitable for preparing pharmaceutical compositions for oral, rectal and topical use.

REFERENCES:
patent: 4564614 (1986-01-01), Crawford et al.
patent: 4565807 (1986-01-01), Uekama et al.
patent: 4603123 (1986-07-01), Chiesi et al.
patent: 4636343 (1987-01-01), Shibanai
patent: 4672061 (1987-06-01), Crawford et al.
patent: 4824841 (1989-04-01), Chiesi et al.
patent: 4888343 (1989-12-01), Jones et al.
patent: 4942167 (1990-07-01), Chiesi et al.
patent: 5068226 (1991-11-01), Weinshenker et al.
patent: 5070081 (1991-12-01), Majid et al.
Szejtli, Cyclodextrin Technology, pp. 279-281 (1988).
Duchene et al, Acta Pharmaceutica Technol., vol. 36, No. 1, pp. 1-6 (1990).

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