Process for preparing phosphorothioates and phosphates and phosp

Details Process for preparing phosphorothioates and phosphates and phosp Process for preparing phosphorothioates and phosphates and phosp

1987-03-20

1989-03-21

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544243, 544337, 558162, 558190, 558192, 558193, 558196, 558197, 558206, 558210, 558211, 558212, 558215, C07F 958, C07F 965, C07F 909

Patent

active

048144517

ABSTRACT:
Certain phenyl and N-heterocyclic phosphorothioates and phosphonothioates and phosphates are prepared by the reaction of an appropriate alkali metal or alkaline earth metal --0-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate, phosphorochloridothioate, phosphonochloridate or phosphonochloridothioate under alkaline conditions in the presence of a tertiary amine catalyst and a nonionic surfactant having an HLB Value of from about 1 to about 20, preferably about 5 to 15, in a two-phase system, one phase being primarily the phosphorate or phosphonate reactant and a complex thereof with the tertiary amine catalyst and the other phase being an aqueous reaction medium comprising water, a buffer system, and the alkali metal or alkaline earth metal-O-phenyl or --O-N-heterocyclic compound, in the substantial or complete absence of an organic solvent the aqueous reaction medium being maintained at pH about 10 to 12 by the buffer system.

REFERENCES:
patent: 3907815 (1975-09-01), Kroposki et al.
patent: 3917621 (1975-11-01), Kroposki et al.
patent: 3928370 (1975-12-01), Wang et al.
patent: 3972887 (1976-08-01), Freedman
patent: 4007197 (1977-02-01), Freedman et al.
patent: 4092312 (1978-05-01), Kroposki et al.
patent: 4094873 (1978-06-01), Kroposki et al.
patent: 4096210 (1978-06-01), Freedman et al.
patent: 4147866 (1979-04-01), Freedman et al.
Krishnakumar, V. K.; Synthetic Communications; 14(2); pp. 189-196 (1984).

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