Process for preparing phosphonyloxyacyl amino acids and derivati

Details Process for preparing phosphonyloxyacyl amino acids and derivati Process for preparing phosphonyloxyacyl amino acids and derivati

1988-08-26

1989-12-05

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

548113, C07F 921

Patent

active

048853801

ABSTRACT:
A process is provided for preparing phosphonyloxyacylamino acids and derivatives thereof having the structure ##STR1## wherein ##STR2## which includes the steps of treating a phosphonic acid dichloride of the structure ##STR3## with an .alpha.-hydroxy acid of the structure ##STR4## in the presence of base such as triethylamine at reduced temperatures to form the cyclic mixed anhydride of the structure ##STR5## (which is a new intermediate) and reacting the cyclic mixed anhydride with an amino acid or ester of the structure

REFERENCES:
patent: 4168267 (1979-09-01), Petrillo
patent: 4427665 (1984-01-01), Karanewsky et al.
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4616005 (1986-10-01), Karanewsky et al.
Baylis, et al, J. Chem. Soc. Perkin Trans. 1, 2845 (1984).
Kosolapoff et al, "Organic Phosphonous Compounds", Wiley-Interscience, N.Y. 1972, vol. 4, pp. 288 and 294-295 and vol. 7, p. 11.
Mehrotra, Can. J. Chem., 63, 663 (1985).
Ramirez, Tetrahedron 29, 3741 (1973).

Affiliated with

Also associated with

Rating

Process for preparing phosphonyloxyacyl amino acids and derivati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing phosphonyloxyacyl amino acids and derivati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing phosphonyloxyacyl amino acids and derivati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2035298