Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1978-01-18
1978-12-05
Myers, Jane S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C07C 5100, C07C 6354
Patent
active
041285727
ABSTRACT:
This invention relates to a process for preparing phenylacetic acid. In particular, the present invention relates to a catalytic process for the synthesis of the alkaline salts of phenylacetic acid by carbonylation of benzyl halides in a diphase system in the presence of cobalt carbonyl complexes. More particularly, the present invention relates to a process for preparing alkaline salts of phenylacetic acid by reacting a benzyl halide selected from chloride and bromide with carbon monoxide in the presence of a catalyst consisting in a salt of cobalt hydrocarbonyl, characterized in that the reaction is conducted in an aqueous/organic diphase system consisting of (a) an aqueous solution of an inorganic alkaline base, and (b) the benzyl halide in an organic solvent, in the presence of a catalyst system composed by a quaternary alkylammonium salt and by a cobalt hydrocarbonyl salt, at atmospheric pressure and at a temperature ranging from 20.degree. to 70.degree. C about.
REFERENCES:
patent: 3116306 (1963-12-01), Heck
patent: 3708529 (1973-01-01), Cassar et al.
patent: 3928429 (1975-12-01), El-Chahowi et al.
patent: 4034004 (1977-07-01), Cassar et al.
Organic Syntheses, Collective, vol. I, pp. 107-109.
Cassar Luigi
Foa Marco
Montedison S.p.A.
Myers Jane S.
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