Process for preparing pharmaceutical compound and...

Details Process for preparing pharmaceutical compound and... Process for preparing pharmaceutical compound and...

2008-06-13

2011-11-01

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S021100, C530S317000, C530S333000

Reexamination Certificate

active

08048853

ABSTRACT:
The present invention relates to novel intermediates of formula VII,or an acid addition salt or a solvate thereof, wherein R1is —(CO)NH2, —CH2NH2or —CN;R2=R3=H or R2and R3together form a cyclic boronate or borate ester;X is a helping group selected from the group consisting of i) a five or six membered heterocyclic aromatic ring and derivatives thereof comprising at least one N-atom being a part of an imine-group, wherein said N-atom forms the point of connection to the cyclohexapeptide ring, and ii) tetrazolyl and derivatives thereof for which a nitrogen atom forms the point of connection to the cyclohexapeptide ring, and a process for the preparation of caspofungin utilizing said intermediates.

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EPO Office Action dated May 24, 2011.

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