Process for preparing pharmaceutical composition containing a he

Details Process for preparing pharmaceutical composition containing a he Process for preparing pharmaceutical composition containing a he

1999-11-23

2000-11-07

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514604, 548507, 564105, A61K 31166, A61K 3118, A61P 1106, C07C30702, C07D20910

Patent

active

061437751

ABSTRACT:
The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy-carbonyl)amino-1-methylindol-3-yl-methyl]-3-methox ybenzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxy benzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.

REFERENCES:
patent: 5294636 (1994-03-01), Edwards et al.
patent: 5319097 (1994-06-01), Holohan
T.S. Kondra'eva, The Technology of Therapeutic Forms, Meditsina, 1991, pp. 85-88, including translation.
I.M. Rabinovich, The Use of Polymers in Medicine, Leingrad Meditsina, 1972, pp. 16-17, including translation.
Haleblian, J., et al., "Pharmaceutical Applications of Polymorphism", J. Pharmaceutical Sciences, vol. 58, No. 8, Aug. 1969, pp. 911-929.

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