Process for preparing pesticidal intermediates

Details Process for preparing pesticidal intermediates Process for preparing pesticidal intermediates

2001-11-02

2003-09-16

Rotman, Alan L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S377100

Reexamination Certificate

active

06620944

ABSTRACT:

This invention relates to novel processes for preparing, pesticides or pesticidal intermediates (particularly 5-amino-1-aryl-3-cyanopyrazole derivatives).
European Patent Publication Nos. 0295117 and 0234119 describe the preparation of pesticidally active phenylpyrazole compounds and of 5-amino-1-aryl-3-cyanopyrazole intermediate compounds used in their synthesis.
Various methods for preparing these compounds are known. The present invention seeks to provide improved or more economical methods for the preparation of pesticides and the intermediate compounds useful in preparing them.
It is a first object of the present invention to provide a convenient process for preparing pesticidally active phenylpyrazole compounds or 5-amino-1-aryl-3-cyanopyrazole pesticidal intermediates, which are obtained in high yield and high purity.
It is a second object of the present invention to provide a convenient process for preparing pesticidally active phenylpyrazole compounds or 5-amino-1-aryl-3-cyanopyrazole pesticidal intermediates, which proceeds without the need for a diazotisation step and hence avoids problems such as hazards known to occur for such reactions.
It is a third object of the present invention to provide a process for preparing pesticidally active phenylpyrazole compounds or 5-amino-1-aryl-3-cyanopyrazole pesticidal intermediates, which is simple to perform and uses less expensive starting materials than known methods.
It is a still further object of the present invention to provide novel intermediates in the manufacture of pesticidally active compounds.
These and other objects of the invention will become apparent from the following description, and are achieved in whole or in part by the present invention.
The present invention accordingly provides a process (A) for the preparation of a compound of formula (I):
wherein W represents nitrogen or —CR
4
;
R
1
represents halogen, haloalkyl (preferably trifluoromethyl), haloalkoxy (preferably trifluoromethoxy), R
5
S(O)
n
—, or —SF
5
;
R
2
represents hydrogen or halogen (for example chlorine or bromine);
R
3
represents hydrogen or R
6
S(O)
m
—;
R
4
represents halogen (for example chlorine or bromine);
R
5
and R
6
represent alkyl or haloalkyl; and
m and n represent 0, 1 or 2; which process comprises the reaction of a compound of formula (II):
 wherein R
1
, R
2
, R
3
and W are as hereinbefore defined, R
7
represents a leaving group (preferably chlorine or bromine) and R
8
represents chlorine or bromine (preferably R
7
and R
8
each represent chlorine), with a cyanide salt. The reaction proceeds via dicyano intermediates of formula (III):
 wherein R
1
, R
2
, R
3
and W are as hereinbefore defined, which generally cyclise under the conditions of the reaction, thus providing a simple and convenient process. Optionally the intermediates of formula (III) may be cyclised in the presence of base according to known methods. Compounds of formula (II) and (III) may exist as a mixture of syn and anti isomers.
Unless otherwise specified in the present specification ‘alkyl’ means straight- or branched-chain alkyl having from one to six carbon atoms (preferably one to three). Unless otherwise specified ‘haloalkyl’ and ‘haloalkoxy’ are straight- or branched-chain alkyl or alkoxy respectively having from one to six carbon atoms (preferably one to three) substituted by one or more halogen atoms selected from fluorine, chlorine or bromine.
Suitable cyanide salts for the above reaction to form compounds of formula (I) include alkali metal cyanides such as potassium, sodium or lithium cyanide, alkaline earth metal cyanides or ammonium cyanide. Potassium cyanide or sodium cyanide are preferred. The reaction is generally conducted in a solvent. Solvents suitable for use include nitriles such as acetonitrile, amides such as N-methylpyrrolidinone, sulphoxides such as dimethylsulphoxide, ethers such as tetrahydrofuran or alcohols such as ethanol. Water may be employed as a co-solvent. The reaction temperature is generally from about −20° C. to the reflux temperature of the solvent, and preferably from about 0° C. to about 20° C.
Generally from two to 5 molar equivalents of cyanide and preferably from about two to about three equivalents are employed.
In formulae (I), (II) and (III) and in the formulae depicted hereinafter, preferred values of the symbols are as follows:
R
1
represents haloalkyl (preferably trifluoromethyl), haloalkoxy (preferably trifluoromethoxy) or —SF
5
;
W represents —CR
4
;
R
2
and R
4
represent halogen (preferably chlorine);
R
3
represents a hydrogen atom, or R
6
S(O)
m
—; wherein R
6
represents optionally halogenated methyl or ethyl (preferably trifluoromethyl); and R
7
and R
8
represent chlorine.
Particularly preferred compounds of formula (I) include:
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole;
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole;
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinylpyrazole; and
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylsulphinylpyrazole.
The process is particularly useful for preparing compounds in which R
3
represents hydrogen, and most preferably for 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole.
In formulae (II) and (III) and in the formulae depicted hereinafter, the most preferred values of the symbols are as follows:
R
1
represents trifluoromethyl;
W represents —CR
4
;
R
2
, R
4
, R
7
and R
8
represent chlorine; and
R
3
represents hydrogen.
According to a further feature of the present invention the above process (A) can be combined with additional process steps (B) and (C) as defined hereinbelow.
Process step (B); comprises the reaction of a compound of formula (IV):
wherein R
1
, R
2
, R
3
, p
7
and W are as hereinbefore defined, with a chlorinating or brominating agent; to give a compound of formula (II) wherein R
1
, R
2
, R
3
, R
7
, R
8
and W are as hereinbefore defined.
Suitable chlorinating agents are thionyl chloride, phosphoryl chloride, phosphorus trichloride, phosphorus pentachloride or a mixture of triphenylphosphine and carbon tetrachloride. Brominating agents which may be used include thionyl bromide, phosphoryl bromide or a mixture of triphenylphosphine and carbon tetrabromide. Preferably the process is performed using a chlorinating agent. A preferred chlorinating agent is phosphoryl chloride.
Solvents which may be used include ethers, aromatic hydrocarbons such as toluene, aromatic halogenated hydrocarbons such as chlorobenzene, or halogenated hydrocarbons such as dichloroethane.
The reaction temperature is generally from 0° C. to 120° C., preferably from 70° C. to 90° C.
Process step (C) comprises the reaction of an arylhydrazine compound of formula (V):
wherein R
1
, R
2
and W are as hereinbefore defined; with a compound of formula (VI):
R
3
R
7
CHCOR
9
  (VI)
wherein R
3
and R
7
are as defined above, and R
9
represents a leaving group preferably a chlorine or bromine atom (generally both R
7
and R
9
represent a chlorine atom); to give a compound of formula (IV) as defined above. The reaction to obtain compounds of formula (IV) is generally performed in a solvent such as halogenated hydrocarbons for example dichloromethane, ethers for example tetrahydrofuran or dioxan, or N,N-dialkylamides for example N,N-dimethylformamamide, and at a temperature of from −20° to 50° C., preferably from 0 to 20° C.
The above combination of process step (A), preceded by process step (B), preceded by process step (C), represents in certain aspects an improvement over the prior art.
Compounds of formula (II) and (IV) above are novel and therefore constitute a further feature of the present invention.
Where R
3
is other than hydrogen, compounds of formula (III) are novel.
Compounds of formula (VI) are known.
The intermediate 5-amino-1-aryl-3-cyanopyrazole compounds of formula (I) obtained by the process (A) of the invention wherein R
3
represents hydrogen, may be used in the preparation of pestic

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