Process for preparing peptide synthons

Details Process for preparing peptide synthons Process for preparing peptide synthons

1991-03-05

1992-08-11

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530334, 530338, C07K 300, C07K 304

Patent

active

051380374

ABSTRACT:
The present invention relates to a process for preparing optically active synthons, in which an oxygen-silylated amino acid or peptide having a protected nitrogenous group, is activated by a non-coordinated halogenated phosphorus derivative and is condensed with an N-silyl amino acid or peptide in which the acid group is protected.

REFERENCES:
patent: 4725645 (1988-02-01), Anteunis et al.
Fournier, A., et al. Int. J. Peptide Protein Res., 31:86-97, 1988.
Vanfleteren, L., et al., Bull. Soc. Chim. Belg., 97:505-517, 1988.
Tung, R. D., et al., J. Org. Chem., 51:3350-3354, 1986.
Le-Nguyen, D., et al., J. Chem. Soc. Perkin Trans., I:1915-1919, 1987.
Kricheldorf, H., Liebigs Ann. Chem., 763:17-38, 1972.
Ramage, R., Peptides, Proc. Eur. Pept. Symp., 17th, Meeting Date 1982; 157-162, 1983.
Miyazawa et al., Peptide Chemistry, 1982, pp. 69-74.
Arnold et al., Synthetic Reactions of Dimethylformamide XIV., 1961.

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