Process for preparing penicillins derivatives

Details Process for preparing penicillins derivatives Process for preparing penicillins derivatives

1975-10-30

1977-02-08

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243C, 2603067C, C07D49944, C07D49942

Patent

active

040071685

ABSTRACT:
The process consists in reacting 2-oxazolidinone or 5-methyl-2-oxazolidinone, with trimethylchlorosilane or dimethylchlorosilane, or triethylchlorosilane, in the presence of an organic tertiary base acting as a hydrogen chloride removal agent, the resulting compound is reacted with 6-APA, 7-ACA or 7-ADCA; the resulting compound is reacted with an activated carboxylic acid to obtain an N-acyl derivative, which, when treated with water or alcohols gives a penicillin or cephalosporin.

REFERENCES:
flynn, "Cephalosporin & Penicillins," p. 81, (1972).
Chemical Abstracts, vol. 59, p. 2826, (1963), (Belg. Pat. No. 615,401).

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