Process for preparing oxiranemethanamine derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546169, 544147, 5483111, 549 28, 549 60, 549473, C07D30336, C07D40512

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058471693

ABSTRACT:
A process for preparing oxiranemethane derivatives which are useful as intermediates for preparing aspartyl protease inhibitors comprising the steps of activating an aminodiol, acylating the aminodiol and reacting the acylated aminodiol with a base to form an epoxy compound.

REFERENCES:
patent: 5648511 (1997-07-01), Ng et al.
Girijavallabhan et al., Bioorganic and Medicinal Chem., vol. 2(10), pp. 1075-1083 1994.

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