Process for preparing oxazoles

Details Process for preparing oxazoles Process for preparing oxazoles

1978-07-17

1980-02-26

Tovar, Jose

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424272, C07D26332, A61K 3142

Patent

active

041905849

ABSTRACT:
(4,5-Diaryloxazol-2-yl)propionic and butyric acids having anti-inflammatory activity had previously been prepared by esterification of aroylarylcarbinols with a reactive derivative of butanedioic and pentanedioic acids, for instance, succinic or glutaric anhydride, isolation of the keto ester so formed and cyclization of the keto ester with a nitrogen-donating cyclizing agent, for instance, ammonium acetate in acetic acid. It has now been found that the omission of the isolation of the keto ester intermediate improves the purity of the oxazole product.

REFERENCES:
patent: 3578671 (1971-05-01), Brown

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