Process for preparing oxazepinones

Details Process for preparing oxazepinones Process for preparing oxazepinones

1985-10-15

1987-05-19

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540488, C07D26714, C07D26708, C07D28110, C07D28104

Patent

active

046670319

ABSTRACT:
Oxazepinones and thiazepinones correspoding to the formula: ##STR1## are prepared by mixing an alkali metal salt corresponding to the formula ##STR2## with oxalyl chloride or bromide in an inert solvent and heating to effect halogenation and fusion, A in the formulas representing a substituted or unsubstituted benzene, naphthalene, or pyridine ring bearing up to two Y substituents; E being oxygen or sulfur; R being an alkyl, cycloalkyl, or phenalkyl group or a substituted phenalkyl group bearing up to two ar-Y substituents; X being chloro or bromo; M being an alkali metal; n being one or two; and Y being a substituent selected from alkyl, alkoxy, trifluorimethyl, nitro, and halo. The products are useful as pharmaceutical intermediates.

REFERENCES:
March "Advanced Organic Chemistry" 2nd edition, (McGraw Hill), p. 633.

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